Ashwagandha

(Withania somnifera)

Ashwagandha is a non native plant which can only be cultivated in certain areas of this country. I have only included it in this website because I feel it is the best adaptogenic plant I have ever used. I am not a medical professional, and I am not attempting to give medical advice. You should always consult a licensed physician before starting any herbal regime. The information contained herein will be a mixture of clinical studies, anecdotal evidence, and my own personal experiences.

Other Names:

Withania, Winter Cherry, Indian Winter Cherry, Indian Ginseng, Ashwagandha

Range:

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Family:

Solanaceae – Nightshade family

Habitat:

It is found online, in healthfood stores, local grocery stores, or perhaps even your spice cabinet.

Parts Used:

Roots

Culinary Uses:

None Known

The following text is meant for informational purposes only. It is not meant to diagnose or treat any illness or injury. Always consult with a physician or other qualified medical care provider concerning the diagnosis and treatment of any illness or injury.

Energetics

Taste: Salty
Thermal: Warming
Humidity: Moistening

Traditional Medicinal Uses:

Ashwagandha root has been used in Ayurvedic medicine for centuries. It is used to treat Alzheimer’s disease and memory problems, auto-immune disorders, arthritis and carpel tunnel, stress, and as a sexual tonic. It increases general stamina, and long-term endurance. Clinical triels outlined in the link below have demonstrated the efficacy of W. somnifera at improving cardiorespiratory endurance. I have personally seen this root work wonders in the treatment of anxiety, decreased energy, stamina, and strength.

Here is a link to a published paper outlining the findings of one of the myriad scientific studies performed demonstrating the efficacy of Ashwagandha, Withania somnifera, on a host of devastating diseases.

This link takes you to a published paper demonstrating the "Efficacy of Ashwagandha (Withania somnifera) in improving cardiorespiratory endurance in healthy athletic adults".

Indications

Alzheimer's, Anxiety, Asthma, Bronchitis, Dementia, Depression, Dyspepsia, Emaciation, Erectile Dysfunction, Fatigue, Fibromyalgia, Hypothyroidism, Impotence, Insomnia, Insulin Resistance, Low Libido, Obstructive Sleep Apnea (OSA), PTSD, Scabies, Sexual Dysfunction, Ulcer

Usage Citations

The fact that studies concerning all indications listed above have not yet been completed, does not mean said uses are invalid. The plants I have included have a long history of effective use, and most were part of the U.S. Pharmacopia prior to the advent of allopathic medicine.

Anxiety: Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. J Integr Complement Med. 2024 May;30(5):459-468. doi: 10.1089/jicm.2023.0279. Epub 2023 Oct 25. PMID: 37878284.

Arthritis: Kanjilal S, Gupta AK, Patnaik RS, Dey A. Analysis of Clinical Trial Registry of India for Evidence of Anti-Arthritic Properties of Withania somnifera (Ashwagandha). Altern Ther Health Med. 2021 Nov;27(6):58-66. PMID: 34144529.

Asthenia (Physical weakness or a lack of energy): Verma N, Gupta SK, Patil S, Tiwari S, Mishra AK. Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO 2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study. F1000Res. 2024 Apr 8;12:335. doi: 10.12688/f1000research.130932.2. PMID: 38988644; PMCID: PMC11234080.

Covid-19: Singh H, Yadav B, Rai AK, Srivastava S, Saiprasad A, Jameela S, Singhal R, Muralidharan S, Mohan R, Chaudhary S, Rana R, Khanduri S, Sharma BS, Chandrasekhararao B, Srikanth N, Dhiman KS. Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial. Complement Ther Med. 2023 Sep;76:102966. doi: 10.1016/j.ctim.2023.102966. Epub 2023 Jul 22. PMID: 37482107.

Depression: Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. J Integr Complement Med. 2024 May;30(5):459-468. doi: 10.1089/jicm.2023.0279. Epub 2023 Oct 25. PMID: 37878284.

Emaciation (Unusual thinness and or weakness): Vaidya VG, Naik NN, Ganu G, Parmar V, Jagtap S, Saste G, Bhatt A, Mulay V, Girme A, Modi SJ, Hingorani L. Clinical pharmacokinetic evaluation of Withania somnifera (L.) Dunal root extract in healthy human volunteers: A non-randomized, single dose study utilizing UHPLC-MS/MS analysis. J Ethnopharmacol. 2024 Mar 25;322:117603. doi: 10.1016/j.jep.2023.117603. Epub 2023 Dec 19. PMID: 38122911.

Fatigue (Excess tiredness): Smith SJ, Lopresti AL, Fairchild TJ. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2023 Nov;37(11):1091-1104. doi: 10.1177/02698811231200023. Epub 2023 Sep 23. PMID: 37740662; PMCID: PMC10647917.

Hypothyroidism (Underactive thyroid): Sharma, Ashok Kumar, Indraneel Basu, and Siddarth Singh. "Efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial." The Journal of Alternative and Complementary Medicine 24, no. 3 (2018): 243-248.

Subclinical Hypothyroidism (Underactive thyroid): Sharma AK, Basu I, Singh S. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. J Altern Complement Med. 2018 Mar;24(3):243-248. doi: 10.1089/acm.2017.0183. Epub 2017 Aug 22. PMID: 28829155.

Low Cardiorespiratory Endurance (Inefficient oxygen delivery to the muscles): Tiwari S, Gupta SK, Pathak AK. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. J Ethnopharmacol. 2021 May 23;272:113929. doi: 10.1016/j.jep.2021.113929. Epub 2021 Feb 15. PMID: 33600918.

Infertility: Gupta A, Mahdi AA, Shukla KK, Ahmad MK, Bansal N, Sankhwar P, Sankhwar SN. Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz. J Ethnopharmacol. 2013 Aug 26;149(1):208-14. doi: 10.1016/j.jep.2013.06.024. Epub 2013 Jun 21. PMID: 23796876.

Insomnia: Langade D, Thakare V, Kanchi S, Kelgane S. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021 Jan 10;264:113276. doi: 10.1016/j.jep.2020.113276. Epub 2020 Aug 17. PMID: 32818573.

Low libido (Low sex drive): Chauhan, Sanjaya, Manoj K. Srivastava, and Anklesh K. Pathak. "Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial." Health Science Reports 5, no. 4 (2022): e741.

Metabolic Syndrome (Multiple cardiovascular disorders): Agnihotri, Akshay P.; Sontakke, Smita D.; Thawani, Vijay R.1; Saoji, Anand; Goswami, Vaidya Shishir S.2. Effects of Withania somnifera in patients of schizophrenia: A randomized, double blind, placebo controlled pilot trial study. Indian Journal of Pharmacology 45(4):p 417-418, Jul–Aug 2013. | DOI: 10.4103/0253-7613.115012

Mild Cognitive Impairment (MCI): Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. J Diet Suppl. 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21. PMID: 28471731.

Non-Restorative Sleep (NRS): Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020 Aug;72:28-36. doi: 10.1016/j.sleep.2020.03.012. Epub 2020 Mar 21. PMID: 32540634.

Oligospermia (Low sperm count): Nasimi Doost Azgomi R, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, Ahmadi AsrBadr Y, Zomorrodi A. Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial. Andrologia. 2018 Sep;50(7):e13041. doi: 10.1111/and.13041. Epub 2018 May 16. PMID: 29770466.

Obsessive Compulsive Disorder (OCD): Obsessive Compulsive Disorder (OCD): Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour B, Mohammadpour AH, Sahebkar A. Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial. Complement Ther Med. 2016 Aug;27:25-9. doi: 10.1016/j.ctim.2016.03.018. Epub 2016 Apr 9. PMID: 27515872.

Perimenopause (Transitioning toward menopause): Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021 Dec;47(12):4414-4425. doi: 10.1111/jog.15030. Epub 2021 Sep 22. PMID: 34553463.

Rheumatoid Arthritis: (RA): Ansari UAMA, Uddin Q, Husain N, Ahmad T, Fatima SH, Minhajuddin A. Evaluation of the efficacy and safety of a herbal formulation for rheumatoid arthritis - A non-inferiority randomized controlled trial. J Ethnopharmacol. 2024 May 10;325:117833. doi: 10.1016/j.jep.2024.117833. Epub 2024 Feb 3. PMID: 38316221.

Sarcopenia (common): Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015 Nov 25;12:43. doi: 10.1186/s12970-015-0104-9. PMID: 26609282; PMCID: PMC4658772.

Schizophrenia: Chengappa KNR, Brar JS, Gannon JM, Schlicht PJ. Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study. J Clin Psychiatry. 2018 Jul 10;79(5):17m11826. doi: 10.4088/JCP.17m11826. PMID: 29995356.

Sexual Dysfunction: Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int. 2015;2015:284154. doi: 10.1155/2015/284154. Epub 2015 Oct 4. PMID: 26504795; PMCID: PMC4609357.

Stress: Speers, Alex B., Kadine A. Cabey, Amala Soumyanath, and Kirsten M. Wright. "Effects of Withania somnifera (Ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia." Current neuropharmacology 19, no. 9 (2021): 1468.

Tuberculosis (Consumption): Kumar R, Rai J, Kajal NC, Devi P. Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis. Indian J Tuberc. 2018 Jul;65(3):246-251. doi: 10.1016/j.ijtb.2017.05.005. Epub 2017 May 21. PMID: 29933868.

Medicinal Actions:

Adaptogen, Anti-Inflammatory, Antineoplastic, Antioxidant, Anxiolytic, Aphrodisiac, Nervine, Tonic - Brain, Tonic: Cardiac, Tonic: Nerve, Tonic: Sexual Male

Constituents:

The Major Characteristic Constituents Are Steroidal Lactones Collectively Known As “withanolides” Including Withaferin A, 27-deoxywithaferin A, Withanolide D, Withanosides I–xi, And Withasomniferols A–c. Alkaloids Constitute The Other Major Group Of Compounds Found In This Plant Material. Among The Alkaloids Found In The Root Are Anaferine, Anahygrine, Cuscohygrine, Dl-isopelletierine, 3-tropyltigloate, Tropane-3-??-ol, 3-??-tigloyl-oxy-tropane And Tropine. Also Present Are Saponins Including Sitoindosides Vii–x

Fruit: Chamase, Cysteine, Cystine, Hydroxyproline

Leaf: 14-alpha-hydroxywithanolide, 14-hydroxy-27-deoxywithaferin A, 17-alpha-hydroxywithanolide, 2-3-dihydrowithaferin, 2-3-dihydrowithanolide, 27-deoxywithaferin, 27-hydroxywithanolide-d, 4-beta-20-alpha-®-dihydroxy-1-oxo-5-beta-6-beta-epoxywith-2-enolide, 4-beta-20-alpha-dihydroxy-1-oxo-5-beta-6-beta-epoxywitha-2-24-dienolide, 4-beta-hydroxy-1-oxo-5-beta-6-beta-epoxywith-2-enolide, 4-beta-hydroxywithanolide, 4-o-caffeoylquinic-acid, 7-beta-hydroxywithanolide, Alkaloids, Beta-sitosterol, Chlorogenic-acid, Dihydrowithaferin A, Isochlorogenic-acid-c, Quercetin, Quercetin-3-rutinoside-7-glucoside, Quinic-acid, Rutin, Withacnistin, Withaferin, Withaferin-a, Withaferine, Withaferins, Withanicandrin, Withanolide F, Withanolide H, Withanolide J, Withanolide K, Withanolide L, Withanolide M, Withanolide P, Withanolide Q, Withanolide R, Withanolide-d, Withanolide-e, Withanolide-g, Withanolide-n, Withanolide-o, Withanolide-s, Withanone

Plant: 1,3,20-trihydroxy-5,24-withadienolide, 14,20r,27-trihydroxy-1-oxo-3,5,24-withatrienolide, 14-hydroxywithanolide-d, 17-hydroxywithanolide-d, 2,3-dehydrosomnifericin, 20-28-dihydroxy-1-oxowitha-2-5-8(14)-24-tetraenolide, 24-ethylcholest-5-en-3-beta-ol, 24-ethylcholesta-5-(z)-24(28)-dien-3-beta-ol, 24-methylcholesta-5,24-dien-3beta-ol, 24-methylcholesta-5-24(25)-dien-3-beta-ol, 27-hydroxywithanolide-d, 5,20alpha-®-dihyroxy-6alpha,7alpha-epoxy-1-oxo-(5alpha)-with A-2,24-dienolide, 5,24-stigmastadien-3-ol, 5,6-epoxy-20-hydroxy-1,4-dioxo-2,24-withadienolide, 5,6-epoxy-20-hydroxy-1,4-dioxo-2-withenolide, 5,6-epoxy-4,17-dihydroxy-1-oxo-2,24-withadienolide, 5,6-epoxy-4,20-dihydroxy-1-oxo-2-withenolide, 5,6-epoxy-4,20-dihydroxy-1-oxo-24-withenolide, 5-beta-6-beta-epoxy-14-17-20-trihydroxy-1-oxowitha-2-24-dienolide, 5-beta-6-beta-epoxy-4-14-17-20-tetrahydroxy-1-oxowitha-2-24-dielolide, 5alpha,17alpha-®-dihyroxy-6alpha,7alpha-epoxy-with A-2,24-dienolide, 6,7-epoxy-5,27-dihydroxy-1-oxo-2,24-withadienolide, Alpha-withananine, Ipuranol, Kno3, Linoleic-acid, N-hentriacontane, Pseudowithanine, Quresimine-a, Quresimine-b, Scopoletin, Sominolide, Sominone, Somniferianine, Somnifericin, Somniferinine, Somnine, Somnirol, Somnisol, Somnitol, Stearic-acid, Stigmasterol, Withaferin-a, Withaferinil, Withaferinol A, Withalactone, Withanic-acid, Withanolide-d, Withaoxylactone, Withasomnine, Withasonmidienone

Root: (-)-anaferine, 3-alpha-tigloyloxytropane, 3-tigloylhydroxytropane, 3-tropyltigloate, 3alpha-tigloyoxytropane, 5-alpha-20-alpha-®-dihydroxy-6-alpha-7-alpha-epoxy-1-oxowitha-2,24-dienolide, 5-alpha-27-hydroxy-6-alpha-7-alpha-epoxy-1-oxowitha-2,24-dienolide, Alkaloids, Anaferine, Anahygrine, Beta-sitosterol, Choline, Cuscohygrine, Daucosterol, Dulcitol, Hentriacontane, Hygrine, Ipuranol, Isopelletierine, Nicotine, Pseudotropanaol, Pseudotropine, Sitoindoside-ix, Sitoindoside-vii, Sitoindoside-viii, Sitoindoside-x, Sitoindosides, Somniferine, Starch, Sucrose, Tropanaol, Tropine, Visamine, Withaferin-a, Withananine, Withanine, Withaniol, Withanolide-d, Withasomine, Withasomniferol-a, Withasomniferol-b, Withasomniferol-c, Withasomnine

Seed Oil: Linoleic-acid

Seed: Withanolide Ws-1

Shoot: 4-deoxyphysalolactone, 5-dehydroxywithanolide, Withaferin-a, Withanolide I, Withanolide-d, Withanolide-e, Withanolide-g, Withanone, Withasomniferin A

Stem Bark: Somniferanolide, Somniferawithanolide, Somniwithanolide, Withasomniferanolide, Withasomnilide

Tissue Culture: 2,4-methylene-cholesterol, 24-ethylidene-cholesterol, Beta-sitosterol, Campesterol, Stigmasterol

Cautions According To WebMD

Possible Side Effects:
Excessive doses of ashwagandha have been reported to cause abortions, so pregnant women should avoid this herb. Do not take this herb with other sedatives or anti-anxiety drugs. Large doses can cause diarrhea, stomach upset and vomiting.

Possible Interactions:
W. somnifera can increase the activity of the immune system. Some immunosuppressant medications, such as those used after a transplant, decrease the activity of the immune system. Taking ashwagandha along with these medications might decrease the effects of these medications.

Ashwagandha might cause sleepiness and slowed breathing. Some medications Benzodiazepines, called sedatives, can also cause sleepiness and slowed breathing. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness.

The body naturally produces thyroid hormones. Ashwagandha might increase how much thyroid hormone the body produces. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone

Ashwagandha might lower blood sugar levels. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Ashwagandha might lower blood pressure. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Herbal Preparations For Withania somnifera

00 Capsules

Part Used: Root
Plant State: Dried
Capsules made from dried powdered root are used as Adaptogen, Anthelmintic, Anti-Inflammatory, Antineoplastic, Antioxidant, Anxiolytic, Immunostimulant, Nervine, Tonic - Nerve.
Dosage: 2-3 capsules twice daily as needed.


Tea

Part Used: Root
Plant State: Dried
Preparation Instructions...
Dosage: Enjoy a mug 2 -3 times daily as needed.


Tincture

Part Used: Root
Plant State: Dried
Alcohol Percentage: 50%
Plant to Alcohol Ratio: 1:5
Preparation Instructions...
Dosage: 60-100 drops three times daily as needed.



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